Mechanisms of bile acid mediated inflammation in the liver
نویسندگان
چکیده
منابع مشابه
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury
The mechanism of bile acid induced cholestatic liver injury remains controversial, thus hindering the development of new therapies for these diseases. In this research highlight, we briefly review the evolution of our understanding of the pathogenesis of bile acid induced liver injury, and summarize our recent findings on this topic. Our data suggests that under pathophysiological conditions bi...
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Bile acids are endogenous molecules that originate from the liver and transport via bile to the intestines. They normally regulate cholesterol homeostasis, stimulate lipid solubilization and mediate metabolic signaling. Early studies implicated that disorders of bile acids compositions and concentrations can cause liver injury. Several hydrophobic bile acids are toxic and ample increases of the...
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ژورنال
عنوان ژورنال: Molecular Aspects of Medicine
سال: 2017
ISSN: 0098-2997
DOI: 10.1016/j.mam.2017.06.001